Apo-pramipexole Apotex

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Description

Information about the drug

Pramipexole is a dopamine receptor agonist. The mechanism of action of the drug is to stimulate D2 receptors. The Pramipexole has a direct effect on the dopamine receptor D3, its affinity for the D3 receptor is seven times stronger than any existing dopamine agonist/ which leads to a decrease in dopamine deficiency in the nuclei of the extrapyramidal system and other parts of the brain and elimination of dopamine deficiency in the nerve endings. When dopamine levels rise in the body, prolactin levels fall. The main purpose of this drug is to treat Parkinson’s disease. Along with the treatment of Parkinson’s disease, Pramipexole is used to treat tired legs syndrome. Also, the drug was effective in treating bipolar disorder, although it was not formally created for these purposes.

The drug is well absorbed in the intestine, so the drug is used orally. The bioavailability of the drug is more than 90%. The maximum concentration in the blood is observed within 2 hours after administration of the drug. Pramipexole binds poorly to plasma proteins but it accumulates in red blood cells. The drug penetrates the blood-brain barrier, the placental barrier and is excreted in breast milk. Pramipexole is not metabolized in the organism. The Pramipexole is excreted in the urine unchanged. The half-life of Pramipexole in young people is 8 hours, in the elderly this time is increased to 12 hours.

Applying

Pramipexole is used by athletes primarily to combat gynecomastia and to improve sexual function, which often decreases with certain anabolic steroids administration.

When prolactin and estrogen levels increase significantly, this can lead to gynecomastia (enlargement of the male breast). Not all men will have problems with an increase in prolactin while taking anabolic steroids, as this depends on the dosage and genetic predisposition. Elevated prolactin levels also have a negative effect on the sexual activity of men, mainly manifested in the inability to achieve and maintain an erection. The most famous steroid that leads to this condition is Nandrolone. Those who have problems with an erection often refuse to take Nandrolone, which is fully explained by its effect on potency. However, in most cases, low doses of Pramipexole can offset such problems. In fact, the right combination of steroid hormones in combination with Pramipexole can help achieve the peak of sexual activity.

The last positive effect of Pramipexole is manifested in an increase in the production of Growth Hormone (GH). Although the increase in production cannot be called significant, it is a sufficient basis for increasing growth hormone in serum levels approximately two hours after taking the medicine.

To reduce the prolactin level or for other purposes, the dosage should be applied in the amount of 0.5 mg per day for a week. Some athletes may need a large dosage, but most often it is recommended to start with low doses, so that the body adapts, and to avoid side effects. The dosage can be increased to 1 mg per day. It depends on the individual reaction of your body. The user should smoothly increase the dosage until the desired result is achieved. It isn’t recommended to cancel the drug, because in the case of cancellation the dose is reduced smoothly throughout the week.

For better selection of the dose, you should be tested for hormone levels.

For the uniform action throughout the day, the daily dosage is divided into three doses. The drug should be taken with a glass of water.

Side effects

Most users do not feel any discomfort during the using of this medicine, but sometimes individual intolerance or overdosing may lead to the unwanted effects:

Side effects of the substance Pramipexole

From the nervous system and sensory organs: asthenia, drowsiness / insomnia, hallucinations, delirium, amnesia, confusion, dizziness, anxiety, depression, dysphagia, dystonia, akathisia, impaired thinking, suicidal mood, extrapyramidal syndrome, dyskinesia, tremor, hypoesthesia, hypokinesia, myoclonus, ataxia, impaired coordination of movements, diplopia, accommodation paralysis, conjunctivitis, hearing impairment; in isolated cases (with rapid dose reduction or abrupt cancellation) – malignant antipsychotic syndrome (hyperthermia, muscle rigidity, impaired consciousness, autonomic lability).

From the cardiovascular system and blood (hematopoiesis, hemostasis): orthostatic hypotension, tachycardia, and arrhythmia.

From the respiratory system: shortness of breath, rhinitis, pharyngitis, sinusitis, flu-like syndrome, increased cough.

From the digestive tract: nausea, vomiting, dyspepsia, flatulence, diarrhea, dry mouth, anorexia, constipation.

From the musculoskeletal system: muscle hyper tonicity, cramps in the muscles of the legs, muscle twitching, myasthenia gravis, arthritis, and bursitis.

Other: fever; peripheral edema, sweating, increased intraocular pressure, decreased libido, impotence, weight loss; increased urination, urinary tract infections; pain syndrome, including chest pain, abdominal pain, pain in the lumbosacral spine, neck pain; voice change; increased activity of CPK; allergic reactions

Reaching the dosage of 1.5 mg can cause drowsiness and weakness. Therefore, you mustn’t drive the car under the influence of this drug. You should also refrain from work that requires maximum concentration.

Contraindications

You should not use this drug if you are under 18. You should not use Pramipexole if you have one of the following conditions: renal failure; arterial hypotension; cardiovascular diseases; simultaneous use with dopamine receptor agonists, sedatives, cimetidine, amantadine, ethanol; pregnancy.

Attention!

Be careful! A lot of drugs are made without proper technologies! They can cause additional side effects! We highly recommend you to use Pramipexole from trusted distributors! We check our suppliers!

Warning!

This drug is a medical product and requires following recommendations of its usage and storage. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to keep this drug out of children`s reach!

You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects. Some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also, you must inform your doctor if you taking Pramipexole with other medicines. So physician can prescribe proper treatment and help you to avoid any unpleasant adverse effects.

 

What advantages does registration give?

Registered user gets some advantages:
  1. Notifications on the mail about future special offers;
  2. Promotion of the regular customers with good discounts;
  3. An opportunity to become VIP.

Is it safe to buy drugs in your store?

It is safe and easy, online store THE ROIDS is that place with the most convenient conditions that will save your time and money.

How long should I wait for the order?

We work in Canada and wide amount of the production on the storage allows us to reduce delivery time.

Is your production original?

We cherish our reputation and don’t cooperate with doubtful providers. Every product is produced on the pharmacology factory and tested carefully with multistage quality control system. In the result of strict control every product in the store is original and accords with the dosage and expiration date.

Do you give recommendations of using your production?

We don’t compose individual courses of using, but every product has detailed description of the:
  1. Composition;
  2. Action;
  3. Recommendations for dosage and durability of using;
  4. Possible side effects.

Can you guarantee the delivery of my order?

As we locate in Canada the chance of losing or arrest of your order is extremely small, but we can’t exclude it completely. We make everything to pack and send your order, but we haven’t opportunity to control courier services.

Do you give package tracking code?

It is the first thing we do after the sending. It allows you to see the route of the delivery online.

Do wholesales customers get special offers?

We always glad to cooperate with active customers, giving them profitable offers.

Do you cooperate with sports organizations?

We work hard for developing sports and healthy lifestyle in our country, so sport teams and clubs enjoy the most profitable offers to work with us.

How can I get products for free?

Unique opportunity to try our production for free is for our clients. We give you necessary drug, then you send us your blood test during applying it.

Why the prices in the store so low?

High-quality products should be available for every our client. It is our goal and we realize it every day. In this way we contribute to the sanitation of the population in our country. Direct cooperation with manufacturers excludes intermediaries. It allows us make all pharmacology more cheep.

What should I do if I have problems with the order?

Problematic situations occur extremely rarely, any problem decides fast. Our managers are 24/7 in touch with customers. To decide the problem, reply the message you get when ordering.

How can you confirm the quality of the production?

You can get the answer in two ways:
  1. Searching the laboratory researching of blood, that was given by our clients to confirm the high quality and effectiveness of the production.
  2. Having first-hand knowledge. Order and try our production, then you will not want to search for another provider and become our regular customer.

What kind of payment you accept?

To save your time we offer some ways to pay, you should only choose the best. If you have more questions, please, contact our manager to get information.

Additional information

Brand

Apotex

Product Code

Pramipexole dihydrochloride

Strength

1 mg

Volume

100 tabs

Availability

In Stock

tabs

10, 100

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