Information about the drug
Clen 50 is better known as Clenbuterol was originally developed to help patients with bronchial asthma. Over time, moved to the sport and settled there as an effective fat burner, gained great popularity not only in sports but also among ordinary people who want to lose weight.
The effect of this product on the human body, rather extensive, it acts immediately on several organs of internal secretion, which allows you to attack fat from different sides, just as the process of deposition of new fat is interrupted.
After getting the drug into the blood, first of all the action goes to the adrenal glands, this provokes them to produce adrenaline and norepinephrine. These hormones significantly increase the metabolic rate, by about 20%. Another mechanism of action affects the thyroid gland, namely stimulates the production of hormones T3 and T4, these hormones are responsible for the natural processing of fat into energy.
The main properties of this drug also include the fact that it is able to withstand catabolic processes in the human body. This is a particularly valuable ability as a losing athlete, it is extremely important to keep the typed muscle mass. This makes this drug very relevant for athletes of bodybuilders in the period of preparation for concussions. At that time, when the body lacks nutrients due to a strict diet. Also, Clen 50 contributes to a natural increase in body temperature, it also adds to the total cost of fat by about 5%. In this case, the appetite of a person is significantly reduced, as a result of which the body is forced to use the accumulated resources (fat).
As a beta-2 agonist, Clenbuterol acts as a fat burner, binding to type 2 beta receptors in the adipose and muscle tissue of the human body. After clenbuterol binds to the receptor, a cascade of biochemical reactions is triggered, which leads to an increase in the synthesis of cAMP (cyclic adenosine monophosphate). cAMP, in turn, activates enzymes that mobilize fatty acids from adipocytes (adipose tissue cells).
Under the action of clenbuterol on the beta-2-adrenergic receptors of the presynaptic membrane, the release of norepinephrine and adrenaline, which have a powerful fat-burning effect, is enhanced. Clenbuterol increases the level of basal metabolism by 20-30% of the initial level.
Clenbuterol inhibits the activity of lipoprotein lipase, resulting in the deposition of fat in adipose tissue becomes impossible. Acting on beta-2-adrenergic receptors of the central nervous system, this drug enhances the secretion of thyroid hormones – the body’s natural fat burners.
The unique feature of Clenbuterol is that it is not only a powerful fat burner, but also has a pronounced anti-catabolic effect, protecting muscles from destruction, which is very important during weight loss and drying in bodybuilding. In studies, it was found that the anticatabolic effect of the drug is due to the blocking of Ca2 + dependent and ubiquitin-proteasome proteolysis
How to understand that Clenbuterol is effective?
Everything is extremely simple, when the drug starts to act on you, then you have a slight tremor in your hands.
Clenbuterol effectively burns fat reserves while raising the overall tone of the entire body. There is a proven scheme of its application, which has proved its effectiveness on thousands of users. Begin receiving the drug usually with 20 mcg per day, every two days the dosage is increased by 20 mcg.
In men, the recommended dose of Clenbuterol for drying and losing weight is 120 – 140 mcg per day. In women, the average dose of Clenbuterol for drying and losing weight is 80-100 mcg per day. The course of Clenbuterol has its own subtle features, which must be strictly observed to avoid side effects.
The duration of the course of Clenbuterol is usually 2 weeks, then addiction (tolerance of the receptors) is developed and the effectiveness decreases. After which it is necessary to take a 2-week break using ketotifen, without it, the break is useless, and then repeat the course; without ketotifen, the break should be significantly longer. The need for a break was scientifically substantiated back in 1990: desensitization of beta-adrenergic receptors develops due to phosphorylation of receptors and other biochemical modifications at the level of secondary messengers (kinases, G-proteins, etc.). It takes several days to update these structures.
Ketotifen is an antiallergic drug with a unique ability to restore the sensitivity of beta-2 adrenergic receptors to clenbuterol. This property has been repeatedly proven in studies involving not only patients with asthma, but also isolated lymphocytes. The mechanism of this effect, obviously, is associated not with histamine receptors, but with the inhibition of phosphodiesterase, which regulates the cAMP-dependent metabolism of all cells, which allows extrapolating the results obtained in the work with lymphocytes to adipose tissue.
Similar effects of receptor resensitization were observed in ketotifen and in relation to other beta-agonists, which is confirmed by a large number of studies.
With the help of ketotifen, you can speed up the process of losing weight or drying by 10-20 percent and extend the course to 8 weeks. In addition, ketotifen will help eliminate mental agitation, tremor of the extremities, insomnia and heart palpitations.
At excessively high doses and a violation of the reception schedule, the following violations may occur:
- Sleep disturbance, should refrain from taking the drug in the afternoon;
- Increased sweating;
- Dry mouth;
This drug is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.
You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.