Information about the drug
Apotex Modafinil is a powerful drug for the normalization and adjustment of the user’s mental-emotional state. The drug was made in the middle 80s of the last century and was used for medical purposes to treat a number of diseases, associated with disturbances of sleep and wakefulness. By chemical structure, Modafinil is a eugeroic drug which mainly used for treatment of shift work sleep disorders and excessive daytime sleepiness associated with obstructive sleep apnea. One of the most common diseases associated with sudden sleep is narcolepsy. Modafinil is also recommended for patients suffering from deep depression.
There are other properties of Modafinil: Increasing of the concentration, suppressing of the drowsiness, improving of the body tone, improving memory and reaction.
This drug is also often used by students, who prepare for serious tests or exams.
This medicine helps athletes to concentrate before the competitions, improve reaction and reduce time of the reaction.
The active ingredient of Modafinil is able to stimulate some parts of the brain, thereby improving its work. It also can stimulate sympathetic alpha receptors, enhancing the result of neurotransmitters, namely dopamine and serotonin.
Armored forces of several countries, such as France, the United Kingdoms, India and USA, have interest in modafinil like an alternative drug to amphetamine – the drug, which used in lengthy missions, where soldiers face sleeplessness.
Modafinil has a similar principle of action as ephedrine and also has the same properties: appetite suppression, high energy levels and speed. All these properties are extremely valuable in modern sports. This fact explains the high popularity of Modafinil among athletes of different types of sport, including bodybuilding.
Studies of modafinil (even in people with healthy weight) have shown that it has an effect on reducing appetite / weight loss. All studies of modafinil in the Medline database, occurring for one month or more, which indicate changes in weight, find that modafinil users experience weight loss compared to placebo.
According to the risk of hypersensitivity reactions and few serious adverse psychiatric effects, which will be mentioned below, the European Drug Association has recommended to treating only sleepiness associated with narcolepsy.
As of 2019, the therapeutic mechanism of action of Modafinil for treatment narcolepsy and sleep-wake disorders still remains unknown. It works as an atypical selective dopamine reuptake inhibitor, which acts very weak, and indirectly activates the release of orexin neuropeptides and histamine from the brain structure, called lateral hypothalamus and tuberomammilary nucleus. Respectively all of it may cause the heightened arousal.
Researches found that neuropeptides, called orexins, also known as hypocretins, are involved in the mechanism of action of Modafinil. Orexin neurons are found in the hypothalamus, but are found in many parts of the brain, including areas that regulate wakefulness. Activation of these neurons increases the content of dopamine and norepinephrine in these areas, and excites histaminergic neurons, which increase the level of histamine there. It has been shown in rats that modafinil increases the release of histamine in the brain; the same mechanism of action can take place in humans.
Treatment of the drowsiness and other problems
Using a dosage of 100-200 mg per day, you can get rid of drowsiness and significantly increase the energy level, besides reduce appetite (useful for athletes who act by weight categories). The daily amount of the drug can be used at one time or separated into the equal portions to use in the morning and afternoon. Don’t use this drug in the afternoon without a high necessity, as this can lead to insomnia and anxiety attacks.
Applying in sport
Sportsmen usually use bigger doses because their organisms incurred by heavier loads and need help. The average dose for the athlete is about 100-400 mg per day.
Simple formula is also used to find out the most correct and save dose: 4mg of the drug to the 1 kilogram of the body weight.
It is important to consult your doctor before taking Modafinil, especially for those who:
- has hypersensitive to the drug or other pill components (such as lactose or lactose monohydrate)
- suffered by cardiovascular disease, especially during the intake of other stimulants, or cirrhosis.
- has heart disease, in particular left ventricular hypertrophy or mitral valve prolapse (Asymptomatic mitral valve prolapse is common but not significantly discussed in the context of the use of Modafinil).
Modafinil may reduce the effectiveness of some contraceptives, which can lead to unplanned pregnancy. The drug should not be combined with alcohol.
Follow recommendations of using this drug to overcome its side effects. There are main symptoms:
- Bad mood because of insomnia;
- Bad sleep;
- Sense of anxiety;
- Nasal congestion;
Dangerous adverse effects include:
- Heavy rushes;
- Severe allergic reactions involving liver or blood cells;
- Swelling of the face, mouth, eyes, lips, tongue, legs or throat;
- Trouble with swallowing and breathing, shortness of breath, heat.
Adverse reactions in most cases occur after an overdose. No fatal cases of overdose with pure modafinil were reported.
The drug provides a long period without the need of sleep. Such action can cause psychological addiction. It is not recommended to use Modafinil for more than two weeks.
This drug is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.
You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.