Information about the drug
Nolvadex is an antitumor agent. The active ingredient Tamoxifen (a non-steroidal estrogen antagonist) was invented back in the 60s of the last century. It has the ability to block estrogen receptors located on the surface of tumor cells. For more than half a century of use, this tool has been recognized as one of the safest and most effective tools for fighting breast cancer.
By binding to estrogen receptors, Tamoxifen opens its way to the nucleus of a tumor cell. There he manages to block the activity of the female hormone, which, as you know, is an important component of the process of reproduction of malignant units. As a result, the tumor stops growing. A single dose is accompanied by a 2-3-week activity of the main component.
Nolvadex (Tamoxifen) has the ability to be well absorbed from the digestive tract. Complete absorption occurs after 4-7 hours. In almost 100% volume, the drug binds to plasma proteins. In the liver, Tamoxifen undergoes hydroxylation and demethylation, during which active metabolites are formed. Excretion from the body occurs mainly due to bile, to a lesser extent – through urine.
Nolvadex is a fairly well-known drug for steroid users, worldwide. The chemical name Tamoxifen Citrate is also often used as a commercial one. A drug that has proven to be effective not only in medicine, but also in big-time sports. The drug helps users of anabolic steroids, to feel safe in relation to some side effects that often occur when using too large doses of steroids.
When using steroids which contain testosterone, part of this drug tends to turn into female sex hormones.
This process occurs due to the interaction of testosterone with an enzyme called Aromatase. As a result, the level of free testosterone decreases, but estrogen increases. If you do not take action, then over time this process will lead to a kind of feminization of the male body. Sex hormones have a very large effect on our body. Therefore, if the female hormones exceed the natural norm, then the following unpleasant consequences may occur: Breast growth in men (genomicostomy); The deposition of fat on the female type (hips and buttocks); Excessive accumulation of water, as a consequence of increased pressure in the circulatory system; Also, in some cases, there are sharp changes in mood, like a capricious girl. These are pretty unpleasant consequences, which should be squashed at the very beginning. To do this, and apply Tamoxifen Citrate.
It acts fraudulently for estrogen. The drug binds to estrogen receptors in the cell membrane, thereby preventing this association between true estrogens and cells. As a result, the amount of estrogen in the blood does not change, just the female hormones become inactive.
This allows the athlete to apply higher dosages and make more complex courses of steroids.
This drug will be relevant in the application, both during the course of steroids, and in after the course of therapy.
Using Nolvadex 20 mg during the course helps to lower the level of female hormones. In such cases, a dosage of 10-20 mg per day is applied. If this method does not bring the expected effect, then you have too large dosages of testosterone. In this case, it would be more appropriate to take aroma inhibitors.
Use in post-course therapy, after the expiration of the active action of anabolic steroids, begins after course therapy. The dosage is approximately 40 mg daily for 14 days. After this time, the dosage should be reduced to 20 mg per day, and thus take another 14 days. After four weeks of use, the dosage is usually reduced to 10-15 mg and taken another 10 days.
During taking of Nolvadex (Tamoxifen), it is worth completely eliminating the use of alcohol, especially with concomitant cardiovascular diseases. The men’s liver is under a double blow – it makes testosterone and Tamoxifen work harder. If you add the effects of alcohol, toxic effects may occur that should not occur at all during treatment with Nolvadex.
You should know that the balance in the body of sex hormones should not be disturbed, in a healthy male body, there must be estrogen, they are responsible for several important functions, including sexual desire.
Nolvadex is a potent antiestrogen that can cause serious adverse reactions. However, in comparison with other drugs of this class, it causes less pronounced complications (subject to careful medical supervision). Common side effects include:
- Increased likelihood of thrombophlebitis.
- Pulmonary thromboembolism.
- Weight loss.
- Nausea / vomiting.
- Water retention in the body.
- Intermenstrual bleeding.
- Vague consciousness.
- Hepatic pathology.
- Obstructive jaundice.
- Violation of spermatogenesis.
- Uterine fibroids.
Some adverse reactions do not require any measures; in other cases, qualified medical assistance cannot be dispensed with to stop the toxic effect. For this reason, before buying Tamoxifen and starting treatment, consult your doctor about what to do if certain adverse reactions develop.
- Hypersensitivity, pregnancy, lactation. (With caution).
- Eye diseases (including cataracts),
- hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia,
- severe thrombophlebitis, thromboembolic disease (including a history).
This drug is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.
You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.