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Viagra (Sildenafil) 100MG

$ 50.00$ 45.00

Description

Information about the drug

Viagra (the active ingredient is sildenafil) is a popular tool for improving erectile function in men, however, recently this drug has found wider application both in medicine and in bodybuilding.

Many believe that Viagra is another nitrogen donor, but this is not so. It does not affect the level of NO, but the vessels in the muscles do expand. If true nitric oxide donors increase the level of NO, which increases the concentration of cellular cGMP, which triggers a cascade of reactions, which ultimately leads to relaxation of the vascular wall, Viagra blocks the enzyme phosphodiesterase-5, which destroys cGMP, so its concentration also begins to increase, and the same end result is obtained.

There are a number of advantages that make the use of Viagra in bodybuilding the most promising. The drug slightly reduces blood pressure, has a positive effect on the heart, effectively improves blood flow in the muscles and causes a minimum of side effects. At the same time, it is repelled by a very high cost, but there are cheaper generics (dynamically).

Some mistakenly believe that taking Viagra causes a permanent erection, but this is not so. In the absence of sexual arousal (stimulation), an erection as a rule never occurs.

Properties of the Sildenafil are used not only for increasing potency, but in sports also. Viagra is a type of doping that can increase athlete’s productivity for some time. Thanks to better blood access to the body’s tissues appears burst of energy and endurance increases. It is because of high oxygen content.

Viagra is very popular in bodybuilding – medicine leads to the better rush of blood to the trained muscle, athlete feels light pumping. Matched with anabolic steroids the effect redoubles, as blood permeate fat deposits better, hormones that start lipolysis too. So, there are several useful processes for bodybuilders.

Pharmacological properties

Pharmacodynamics

The physiological mechanism involves the release of nitric oxide (NO). The released nitric oxide activates the guanylate cyclase enzyme, which stimulates the increase of cyclic guanosine monophosphate (cGMP).

Effect on pharmacodynamics:

In vitro studies have demonstrated that sildenafil is selective for PDE5. The effect of sildenafil on PDE5 is more potent than on other known phosphodiesterases. This effect is 10 times more powerful than the effect on PDE6 involved in retinal photoreformation. In particular, the selectivity of sildenafil for PDE5 is 4,000 times greater than its selectivity for PDEZ, a cAMP-specific phosphodiesterase isoform involved in the regulation of cardiac contractility.

Pharmacokinetics

Absorption: Sildenafil is rapidly absorbed. The maximum plasma concentration of the drug is reached within 30-120 minutes after its oral fasting. The average absolute bioavailability after oral administration is 41%. In the recommended dose range (25 to 100 mg), the sildenafil AUC and Cmax after oral administration increase in proportion to the dose.

When using sildenafil while eating, the degree of absorption decreases with an average Tmax elongation of up to 60 minutes and an average Cmax decrease of 29%.

Distribution: The average equilibrium volume of distribution is 105 liters, which indicates the distribution of the drug in the tissues of the body. After single oral administration of 100 mg sildenafil, the mean maximum total plasma concentration of sildenafil is approximately 440 ng / ml. Because the binding of sildenafil and its major N-desmethyl metabolite to plasma proteins is 96%, the mean maximum plasma concentration of free sildenafil is 18 ng / ml (38 nmol). The degree of plasma protein binding is independent of total sildenafil concentrations.

Biotransformation: Sildenafil metabolism is mainly by the involvement of the microsomal isoenzymes of the liver CYP3A4 (major pathway) and CYP2C9 (minor pathway). The major circulating metabolite is formed by N-demethylation of sildenafil. The metabolite selectivity for PDE5 is comparable to that of sildenafil, and the metabolite activity for PDE5 is approximately 50% of the activity of the starting material. The plasma concentration of this metabolite is approximately 40% of the concentration of sildenafil in blood plasma. The N-demethylated metabolite undergoes further metabolism, and its half-life is approximately 4 hours.

Elimination: Sildenafil’s total clearance is 41 l / h, resulting in a half-life of 3–5 hours.

Applying

To use Viagra in therapeutic ways, usually applies 50mg (a half of the tablet) in 40-45 minutes before the act.

In bodybuilding the drug is usually used by professionals, their dose is 100mg a day in 30-60 minutes before the training, considering the warm-up – the medicine will act completely before doing main exercises.

The action of Viagra continues for 6 hours as usual, cells’ susceptibility to the anabolic steroids increases, so athlete can make the endurance better and trains longer, that helps to gain nice result.

Contraindications:

  • Hypersensitivity to the active substance or any of the excipients of the drug.
  • The simultaneous use with nitric oxide donors (such as amyl nitrite) or nitrates in any form is contraindicated, since it is known that sildenafil affects the metabolism of nitric oxide / cyclic guanosine monophosphate (cGMP) and potentiates the hypotensive effect of nitrates.

 Side effects

The product has not strict contraindications, but if you use any drug for heart treatment learn about its joint application.

This drug mustn’t be matched with alcohol – it can be the reason of some side effects. Applying big doses can cause such symptoms:

  • Extremities swelling;
  • Headache;
  • Pain in the chest;
  • Diarrhea;
  • Nose bleeding.

Warning!

This drug is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.

You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.

What advantages does registration give?

Registered user gets some advantages:
  1. Notifications on the mail about future special offers;
  2. Promotion of the regular customers with good discounts;
  3. An opportunity to become VIP.

Is it safe to buy drugs in your store?

It is safe and easy, online store THE ROIDS is that place with the most convenient conditions that will save your time and money.

How long should I wait for the order?

We work in Canada and wide amount of the production on the storage allows us to reduce delivery time.

Is your production original?

We cherish our reputation and don’t cooperate with doubtful providers. Every product is produced on the pharmacology factory and tested carefully with multistage quality control system. In the result of strict control every product in the store is original and accords with the dosage and expiration date.

Do you give recommendations of using your production?

We don’t compose individual courses of using, but every product has detailed description of the:
  1. Composition;
  2. Action;
  3. Recommendations for dosage and durability of using;
  4. Possible side effects.

Can you guarantee the delivery of my order?

As we locate in Canada the chance of losing or arrest of your order is extremely small, but we can’t exclude it completely. We make everything to pack and send your order, but we haven’t opportunity to control courier services.

Do you give package tracking code?

It is the first thing we do after the sending. It allows you to see the route of the delivery online.

Do wholesales customers get special offers?

We always glad to cooperate with active customers, giving them profitable offers.

Do you cooperate with sports organizations?

We work hard for developing sports and healthy lifestyle in our country, so sport teams and clubs enjoy the most profitable offers to work with us.

How can I get products for free?

Unique opportunity to try our production for free is for our clients. We give you necessary drug, then you send us your blood test during applying it.

Why the prices in the store so low?

High-quality products should be available for every our client. It is our goal and we realize it every day. In this way we contribute to the sanitation of the population in our country. Direct cooperation with manufacturers excludes intermediaries. It allows us make all pharmacology more cheep.

What should I do if I have problems with the order?

Problematic situations occur extremely rarely, any problem decides fast. Our managers are 24/7 in touch with customers. To decide the problem, reply the message you get when ordering.

How can you confirm the quality of the production?

You can get the answer in two ways:
  1. Searching the laboratory researching of blood, that was given by our clients to confirm the high quality and effectiveness of the production.
  2. Having first-hand knowledge. Order and try our production, then you will not want to search for another provider and become our regular customer.

What kind of payment you accept?

To save your time we offer some ways to pay, you should only choose the best. If you have more questions, please, contact our manager to get information.

Additional information

Brand

Teragon Labs

Product Code

Sildenafil Citrate

Strength

100 mg

Volume

20 tabs

Availability

In Stock

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